2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N6658
    6-Hydroxy-4-methylcoumarin
    		99.30%
    6-Hydroxy-4-methylcoumarin (compound 9) is a coumarins secondary metabolites and has anticancer activity.
    6-Hydroxy-4-methylcoumarin
  • HY-135384
    tert-Buthyl Pitavastatin
    		98.46%
    tert-Buthyl Pitavastatin is the  metabolite of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
    tert-Buthyl Pitavastatin
  • HY-135389
    Desmethyl Levofloxacin
    		99.77%
    Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
    Desmethyl Levofloxacin
  • HY-W144096
    Methyl 2,4,6-trihydroxybenzoate
    		98.20%
    Methyl 2,4,6-trihydroxybenzoate is a metabolite of 2,4,6-trihydroxybenzoate and exhibits properties as an antioxidant, lipid lowering and anticancer activities.
    Methyl 2,4,6-trihydroxybenzoate
  • HY-121208
    Ketanserinol
    		98.05%
    Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries.
    Ketanserinol
  • HY-13256A
    Desmethyl Erlotinib
    		98.77%
    Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor. Desmethyl Erlotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Desmethyl Erlotinib
  • HY-122440
    Scopoline
    		98.0%
    Scopoline (compound 3a) is a compound formed from Scopine (HY-B0459), an α1 adrenergic receptor agonist.
    Scopoline
  • HY-135556
    Norfluoxetine
    		98.71%
    Norfluoxetine is the active metabolite of antidepressant Fluoxetine (HY-B0102). Norfluoxetine is a selective inhibitor for serotonin uptake.
    Norfluoxetine
  • HY-171128
    PTX-M
    		99.95%
    PTX-M is an oxidized metabolite of Pentoxifylline (HY-B0715). Pentoxifylline is a phosphodiesterase inhibitor that can be used for the study of peripheral vascular, inflammatory, and immune diseases.
    PTX-M
  • HY-W002112S
    (±)-Nornicotine-d4
    		98.0%
    (±)-Nornicotine-d4 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine-d<sub>4</sub>
  • HY-12388AS
    N-Desmethyl clomipramine-d3 hydrochloride
    		99.81%
    N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine
    N-Desmethyl clomipramine-d<sub>3</sub> hydrochloride
  • HY-128379
    Labetalone hydrochloride
    		99.27%
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride
  • HY-117229
    Sonidegib metabolite M48
    		98.0%
    Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib.
    Sonidegib metabolite M48
  • HY-N11224
    Pregnanetriol
    		99.8%
    Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone.
    Pregnanetriol
  • HY-113483
    20-Carboxy-Leukotriene B4
    		98.0%
    20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
    20-Carboxy-Leukotriene B4
  • HY-135604
    Dibutyl phosphate
    Dibutyl phosphate (DBUP) is a urinary metabolite of organophosphate esters (OPEs). Dibutyl phosphate is positively correlated with an increased risk of sarcopenia.
    Dibutyl phosphate
  • HY-W009512
    CVT-2738
    		99.81%
    CVT-2738 is an orally active metabolite of Ranolazine (HY-B0280). CVT-2738 has a protective effect against Isoprenaline (HY-108353)-induced myocardial ischemia in mice. CVT-2738 can be used in myocardial ischemia research.
    CVT-2738
  • HY-W576312
    N,N-Dimethyltryptamine N-oxide
    		99.8%
    N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide
  • HY-129697
    3-Hydroxy Medetomidine
    		≥98.0%
    3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.
    3-Hydroxy Medetomidine
  • HY-W016033
    Pantoprazole sulfide
    		98.83%
    Pantoprazole sulfide is a metabolite of Pantoprazole (HY-17507), which is a proton-pump inhibitor.
    Pantoprazole sulfide
Cat. No. Product Name / Synonyms Application Reactivity